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© 2002 by CRC Press LLC INTERPLAY BETWEEN TRANSPORTERS AND ENZYMES 723 TABLE 23. The foundations for the new test were laid by Kelsey et al. It has been shown that TβR-I and -II can associate in the absence of ligand in vitro and when co- expressed in mammalian jnvestment , two observations giving support for preexisting heterotetramers in the absence of ligand.
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